Samuel Gareginyan was born in Yerevan, Armenia. He graduated from Terlemezian Fine Art College and Yerevan State Academy of Fine Arts (1985-1991).
Samuel exhibited his works in Armenia, Russia, Lebanon, Spain, England, Turkey, Argentina and the United States. His paintings are in permanent collections and archives at the Museum of Modern Arts of Armenia, the Fund of the Artists Union of Armenia, Armenian Library and Museum of America, Museum of Fine Art, Boston.
Since 1997 he lives in the United States exhibiting his works in the galleries and museums of America and abroad.